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• Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors.

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• Iron deficiency is associated with Hypothyroxinemia and Hypotriiodothyroninemia in the Spanish general adult population: Di@bet.es study

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• Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency.

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• TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β.

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• The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.

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• GNIP1 E3 ubiquitin ligase is a novel player in regulating glycogen metabolism in skeletal muscle.

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• Altered expression of miR-181a-5p and miR-23a-3p is associated with obesity and TNFα-induced insulin resistance.

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• Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.

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